Outgoing mail server performance

[TJ]

Hi Guys,
i am looking for some advise to help get the best out of one of my severs.
It is a Dell PowerEdge R420,32GB,2x8c CPU and igb nics.
Its primary purpose is to send outgoing mail it can send up to 3 millon 
emails a day and it running exim.

At the moment the only tweaks i have are:

*Loader.conf*
kern.maxproc=24676
ipc.maxpipekva=277118976
ipc.shmseg=256

*Sysctl.conf*
kern.ipc.somaxconn=2048
net.inet.tcp.sendspace=131072
inet.tcp.recvspace=131072
inet.udp.recvspace=131072
defer_swapspace_pageouts=1
maxfiles=262144
maxfilesperproc=131072
inet.icmp.icmplim=0
ipc.shmall=16384
ipc.maxsockets=65536
inet.tcp.delayed_ack=0
inet.tcp.msl=30000
inet.tcp.slowstart_flightsize=4
ipc.nmbclusters=65536
pmap.shpgperproc=400
pmap.pv_entry_max=18828980

I am relatively new to FreeBSD and would appreciate some pointers on 
improving the performance of this server.

Cheers

TJ