[Bug 269705] net-im/py-matrix-synapse does not run

https://bugs.freebsd.org/bugzilla/show_bug.cgi?id=269705

            Bug ID: 269705
           Summary: net-im/py-matrix-synapse does not run
           Product: Ports & Packages
           Version: Latest
          Hardware: Any
                OS: Any
            Status: New
          Severity: Affects Many People
          Priority: ---
         Component: Individual Port(s)
          Assignee: ports-bugs@FreeBSD.org
          Reporter: dave@jetcafe.org
                CC: ports@skyforge.at
                CC: ports@skyforge.at
             Flags: maintainer-feedback?(ports@skyforge.at)

Given that there have been some openssl/libressl vulnerabilities very recently,
upon attempting to upgrade LibreSSL to 3.5.4 this kind of thing is happening
when I attempt to start synapse after the package upgrade: 

ImportError:
/usr/local/lib/python3.9/site-packages/cryptography/hazmat/bindings/_openssl.abi3.so:
Undefined symbol "DTLS_get_link_min_mtu"

I have tried manually setting this symbol to something defined as a wild
attempt to fix this issue, but the chain of issues continues:

ImportError:
/usr/local/lib/python3.9/site-packages/cryptography/hazmat/bindings/_openssl.abi3.so:
Undefined symbol "EVP_DigestFinalXOF"

I see a libressl patch in py-cryptography's port, but maybe this is not enough?

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